Compound Q&A

How is 2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS: 111992-05-3) typically synthesized?

Answer

2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one
2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one is typically synthesized via a multistep process involving the reaction of a fluoro-substituted phenol with a methylated hydrazine derivative. This process often uses a palladium catalyst and requires mild to moderate reaction conditions. The product shows high selectivity and good yield, making it a valuable intermediate in pharmaceutical synthesis.

About

English Name 2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one
Molecular Formula C10H7ClF3N3O
Molecular Weight 277.63 g/mol
SMILES FC(F)N2\C(=N/N(c1c(F)cc(Cl)cc1)C2=O)C
InChIKey WPCDJTIPGVMACI-UHFFFAOYSA-N
Last Updated: 2026-03-04 21:35

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