2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one(CAS: 111992-05-3)

2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one is a crystalline compound with a molecular weight of approximately 337.02 g/mol. It has limited water solubility and moderate solubility in common organic solvents. It is known for its good stability under normal conditions but can react with strong bases. This compound is often used as an intermediate in the synthesis of other pharmaceuticals and has limited reactivity under standard laboratory conditions.

2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one is typically synthesized via a multistep process involving the reaction of a fluoro-substituted phenol with a methylated hydrazine derivative. This process often uses a palladium catalyst and requires mild to moderate reaction conditions. The product shows high selectivity and good yield, making it a valuable intermediate in pharmaceutical synthesis.

2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one is primarily used in the pharmaceutical industry as an intermediate for the production of other drugs. It is also occasionally used in research for its unique chemical properties, particularly in the development of new drug candidates and in the synthesis of complex molecules.

When handling 2-(4-Chloro-2-fluorophenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. It is advisable to consult the Safety Data Sheet (SDS) for detailed handling and emergency response procedures.