Compound Q&A
How is (1S,2R)-2-{[(1S)-1-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl}cyclohexanecarboxylic acid (CAS: 1432500-66-7) typically synthesized?
Answer
![(1S,2R)-2-{[(1S)-1-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl}cyclohexanecarboxylic acid](https://static.chemtradehub.com/structs/143/1432500-66-7-3a4c.webp "(1S,2R)-2-{[(1S)-1-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl}cyclohexanecarboxylic acid")
The compound is typically synthesized via a multi-step process involving the condensation of a 1,3-dioxo-1,3-dihydro-2H-isoindole-2-carboxylic acid derivative with a 3,4-dihydro-2(1H)-isoquinoline derivative. This process often requires the use of a coupling agent and a catalyst to enhance selectivity and yield. The final product undergoes crystallization to obtain the desired molecular form.
About
CAS No
1432500-66-7
English Name
(1S,2R)-2-{[(1S)-1-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl}cyclohexanecarboxylic acid
Molecular Formula
C26H26N2O5
Molecular Weight
446.5030000000003 g/mol
SMILES
c1ccc2c(c1)CCN([C@@H]2CN3C(=O)c4ccccc4C3=O)C(=O)[C@@H]5CCCC[C@@H]5C(=O)O
InChIKey
LNENLABLFGGAFF-BHIFYINESA-N
Last Updated: 2026-03-04 16:30
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