Compound Q&A
How is (3R,4S)-4-(4-Bromophenyl)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (CAS: 1217829-96-3) typically synthesized?
Answer
(3R,4S)-4-(4-Bromophenyl)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (CAS: 1217829-96-3) is synthesized by the Williamson ether synthesis followed by protection of the primary amine with tert-butoxycarbonyl (Boc) group. The bromophenyl derivative is reacted with tert-butoxycarbonyl chloride in the presence of a base to form the protected pyrrolidine-3-carboxylic acid. This method offers high yield and selectivity.
About
CAS No
1217829-96-3
English Name
(3R,4S)-4-(4-Bromophenyl)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid
Molecular Formula
C16H20BrNO4
Molecular Weight
370.24 g/mol
SMILES
CC(C)(C)OC(=O)N1CC(C(C1)C(=O)O)C2=CC=C(C=C2)Br
InChIKey
MXJJJGPIDKFWKX-OLZOCXBDSA-N
Last Updated: 2026-03-01 17:11
