How is 5-Methoxy-1,3-benzothiazole-2-carbonitrile (CAS: 7267-35-8) typically synthesized?

5-Methoxy-1,3-benzothiazole-2-carbonitrile can be synthesized through the reaction of 1,3-benzothiazole with methanol in the presence of sodium methoxide as a base. The reaction is carried out in an aprotic solvent like dimethylformamide (DMF) at a temperature around 100°C. The process involves the methylation of the thiazole ring followed by the introduction of a nitrile group. The yield of the product is typically around 85-90%, with good selectivity and purity.