Compound Q&A
How is (E)-3-(1,4-Dioxaspiro[4.5]dec-7-en-7-yl)acrylic acid (CAS: 226916-19-4) typically synthesized?
Answer
![(E)-3-(1,4-Dioxaspiro[4.5]dec-7-en-7-yl)acrylic acid](https://static.chemtradehub.com/structs/226/226916-19-4-c550.webp "(E)-3-(1,4-Dioxaspiro[4.5]dec-7-en-7-yl)acrylic acid")
(E)-3-(1,4-Dioxaspiro[4.5]dec-7-en-7-yl)acrylic acid can be synthesized via a Diels-Alder reaction of 1,4-dioxaspiro[4.5]dec-7-ene with acrylic acid. This reaction requires a Lewis acid catalyst such as boron trifluoride etherate. The yield is typically around 70-80%, and the reaction is highly selective, providing good stereocontrol of the product. Further derivatization can be achieved by esterification or amidation reactions.
About
CAS No
226916-19-4
English Name
(E)-3-(1,4-Dioxaspiro[4.5]dec-7-en-7-yl)acrylic acid
Molecular Formula
C11H14O4
Molecular Weight
210.23 g/mol
SMILES
C1CC2(CC(=C1)C=CC(=O)O)OCCO2
InChIKey
FWFDDYZZFODCDR-ONEGZZNKSA-N
Last Updated: 2026-01-07 10:17
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