Compound Q&A
How is 4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid (CAS: 644981-94-2) typically synthesized?
Answer
![4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid](https://static.chemtradehub.com/structs/644/644981-94-2-2949.webp "4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid")
4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid is synthesized via the multistep reaction involving piperidine, 4-chlorophenyl chloroformate, and 2-methyl-2-propanol. The key steps include esterification and piperidine substitution. The reaction typically yields 70-80% purity with the use of a catalytic amount of an acid like trifluoroacetic acid.
About
CAS No
644981-94-2
English Name
4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid
Molecular Formula
C17H22ClNO4
Molecular Weight
339.82 g/mol
SMILES
CC(C)(C)OC(=O)N1CCC(CC1)(C2=CC=C(C=C2)Cl)C(=O)O
InChIKey
UVPSYFHQUVHQJE-UHFFFAOYSA-N
Last Updated: 2026-01-04 19:14
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