4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid(CAS: 644981-94-2)

4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid is a crystalline solid with a molecular weight of approximately 354.73 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and acetonitrile. The compound exhibits moderate reactivity in acidic or basic conditions. It has a melting point range of 128-130°C and is stable under normal laboratory conditions.

4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid is synthesized via the multistep reaction involving piperidine, 4-chlorophenyl chloroformate, and 2-methyl-2-propanol. The key steps include esterification and piperidine substitution. The reaction typically yields 70-80% purity with the use of a catalytic amount of an acid like trifluoroacetic acid.

4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid is primarily used in the pharmaceutical industry as an intermediate in drug synthesis. It is also utilized in the polymer industry for the development of advanced materials and in the production of sensors and semiconductors for their electronic properties.

Proper personal protective equipment (PPE) is essential when handling 4-(4-Chlorophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid. Wear gloves, safety goggles, and a lab coat. Ensure the substance is handled in a well-ventilated area or a fume hood. Spills should be immediately addressed by neutralizing with an appropriate base and cleaning up with absorbent material. Refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.