Compound Q&A
How is (4R,5S)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one (CAS: 875444-10-3) typically synthesized?
Answer
![(4R,5S)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one](https://static.chemtradehub.com/structs/875/875444-10-3-93fd.webp "(4R,5S)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one")
(4R,5S)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one (CAS: 875444-10-3) is typically synthesized via a multistep process involving the protection of an alcohol, followed by the formation of an oxazolidinone ring. The synthesis involves the use of protecting agents such as tert-butyldimethylsilyl chloride and catalytic amounts of trifluoroacetic acid. The yield of the final product is around 65-70%, and the purity is enhanced through recrystallization.
About
CAS No
875444-10-3
English Name
(4R,5S)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
Molecular Formula
C12H9F6NO2
Molecular Weight
313.2 g/mol
SMILES
CC1C(OC(=O)N1)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F
InChIKey
OHIDCVTXTYVGRO-MLUIRONXSA-N
Last Updated: 2026-01-04 19:14
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