Compound Q&A
How is 2-Chloro-4-(trifluoromethoxy)phenol (CAS: 70783-75-4) typically synthesized?
Answer
2-Chloro-4-(trifluoromethoxy)phenol is typically synthesized via the Suzuki-Miyaura coupling reaction, where 4-(trifluoromethoxy)toluene is coupled with chloroformic acid ester in the presence of a palladium catalyst and a base such as cesium carbonate. The yield is usually around 75-85%, and the reaction is carried out under inert atmosphere to avoid decomposition.
About
CAS No
70783-75-4
English Name
2-Chloro-4-(trifluoromethoxy)phenol
Molecular Formula
C7H4ClF3O2
Molecular Weight
212.55 g/mol
SMILES
C1=CC(=C(C=C1OC(F)(F)F)Cl)O
InChIKey
LSTYNKXVEMLNBE-UHFFFAOYSA-N
Last Updated: 2026-01-02 00:31
