Compound Q&A
How is 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole (CAS: 1351478-35-7) typically synthesized?
Answer
![1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole](https://static.chemtradehub.com/structs/135/1351478-35-7-905a.webp "1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole")
This compound is typically synthesized via a Suzuki coupling reaction between 4-bromobenzylamine and tetramethyl-1,3,2-dioxaborolane in the presence of palladium(II) acetate and a ligand. The yield is around 70-80% with good regioselectivity. The reaction is typically performed under microwave-assisted conditions to enhance reactivity and yield.
About
CAS No
1351478-35-7
English Name
1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole
Molecular Formula
C16H21BN2O2
Molecular Weight
284.17 g/mol
SMILES
B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)CN3C=CN=C3
InChIKey
GVBBYQGYCDPTQO-UHFFFAOYSA-N
Last Updated: 2026-01-01 10:50
![1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole — ShangHaiMaiRuiErShengHua Technology Co Ltd](https://static.chemtradehub.com/suppliers/67ced3b52b2de6e8e95a6e52/67ced3b52b2de6e8e95a6e52-logo.webp){kind=logo}
![1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole — ShenZhenAiTaHuaXue Co Ltd](https://static.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fa/67ced0fb2b2de6e8e95a67fa-logo.webp){kind=logo}
![1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-1H-imidazole — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}