Compound Q&A
How is 4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one (CAS: 5543-58-8) typically synthesized?
Answer
![4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one](https://static.chemtradehub.com/structs/554/5543-58-8-55f0.webp "4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one")
4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one is commonly synthesized via a multi-step process involving the condensation of a 1-phenylbutanone derivative with a 1,3-diketone, followed by hydroxylation and dehydrogenation steps. The reaction typically requires the use of a Lewis acid catalyst, such as aluminum chloride, and the overall yield is around 70-80%. The reaction conditions are carefully controlled to ensure high selectivity and purity.
About
CAS No
5543-58-8
English Name
4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one
Molecular Formula
C19H16O4
Molecular Weight
308.333 g/mol
SMILES
O=C(OC1=CC=CC=C12)C([C@@H](C3=CC=CC=C3)CC(C)=O)=C2O
InChIKey
PJVWKTKQMONHTI-OAHLLOKOSA-N
Last Updated: 2026-01-01 10:50
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