4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one(CAS: 5543-58-8)

4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one is a crystalline compound with a molecular weight of approximately 324.31 g/mol. It has a low solubility in water but is soluble in organic solvents like acetone and ethanol. This compound is relatively stable under normal conditions but can react with strong bases and oxidizing agents. It is known for its chromogenic properties and is used in analytical chemistry applications.

4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one is commonly synthesized via a multi-step process involving the condensation of a 1-phenylbutanone derivative with a 1,3-diketone, followed by hydroxylation and dehydrogenation steps. The reaction typically requires the use of a Lewis acid catalyst, such as aluminum chloride, and the overall yield is around 70-80%. The reaction conditions are carefully controlled to ensure high selectivity and purity.

4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one is primarily used in the pharmaceutical and chemical industries for its chromogenic properties. It is also utilized in the polymer industry for its ability to enhance the coloration of polymer compounds. Additionally, it plays a role in the development of sensors and semiconductors due to its structural complexity and reactivity.

When handling 4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one, it is important to use appropriate Personal Protective Equipment (PPE) including gloves, goggles, and a lab coat. The material should be stored in a cool, dry place away from strong oxidizers and bases. In the event of a spill, it should be cleaned up using appropriate methods and materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.