Compound Q&A

How is 1-(2,6-Difluoro-4-methoxyphenyl)ethanone (CAS: 886498-84-6) typically synthesized?

Answer

1-(2,6-Difluoro-4-methoxyphenyl)ethanone
1-(2,6-Difluoro-4-methoxyphenyl)ethanone can be synthesized via a two-step process involving the protection of an alcohol followed by an electrophilic aromatic substitution. Common solvents for the reactions are dichloromethane or tetrahydrofuran. The use of a Lewis acid catalyst, such as aluminum chloride, is typical for the electrophilic substitution step. The overall yield is generally around 70-80%.

About

English Name 1-(2,6-Difluoro-4-methoxyphenyl)ethanone
Molecular Formula C9H8F2O2
Molecular Weight 186.16 g/mol
SMILES CC(=O)C1=C(C=C(C=C1F)OC)F
InChIKey YZVNPIUPAKOREH-UHFFFAOYSA-N
Last Updated: 2026-01-01 06:12

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