How is Methyl beta,beta-difluorophenylalaninate hydrochloride (CAS: 75149-43-8) typically synthesized?

Methyl beta,beta-difluorophenylalaninate hydrochloride is typically synthesized by the esterification of beta,beta-difluorophenylalanine with methyl alcohol in the presence of a catalytic amount of an acid, such as sulfuric acid. The reaction is usually carried out under mild conditions, and the product is then neutralized with a base to form the hydrochloride salt. The reaction yields are generally good, and the product can be isolated by recrystallization.