Compound Q&A

How is 6-Phenyl-1H-indazole (CAS: 1260897-38-8) typically synthesized?

Answer

6-Phenyl-1H-indazole
6-Phenyl-1H-indazole can be synthesized via the indazole synthesis route, where phenylacetyl chloride is condensed with indole in the presence of a base like sodium hydroxide. The reaction typically yields a mixture of isomers, and separation may be required. Alternatively, it can be prepared through the Curtius rearrangement of phenylphosphorane. The overall yield is moderate, around 50-70%, depending on the method and purity of the starting materials.

About

English Name 6-Phenyl-1H-indazole
Molecular Formula C13H10N2
Molecular Weight 194.24 g/mol
SMILES c1ccc(cc1)c2ccc3cn[nH]c3c2
InChIKey OPJICVPEFWXDDJ-UHFFFAOYSA-N
Last Updated: 2025-12-31 11:48

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