Compound Q&A
How is (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-N-ethyl-5-heptenamide (CAS: 1185851-52-8) typically synthesized?
Answer
![(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-N-ethyl-5-heptenamide](https://static.chemtradehub.com/structs/118/1185851-52-8-1737.webp "(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-N-ethyl-5-heptenamide")
The compound is synthesized through a multi-step process involving diaryliodonium salts and boronic acids. The key steps include a Suzuki coupling reaction followed by a Wittig olefination. The reaction requires a catalyst such as Pd(PPh3)4 and is typically carried out in anhydrous tetrahydrofuran (THF). High yield and selectivity are achieved under these conditions.
About
CAS No
1185851-52-8
English Name
(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-N-ethyl-5-heptenamide
Molecular Formula
C24H33F2NO4
Molecular Weight
437.53 g/mol
SMILES
CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/C(COc1ccccc1)(F)F)O
InChIKey
VJZKLIPANASSBD-MSHHKXPZSA-N
Last Updated: 2025-12-31 11:48
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![(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-N-ethyl-5-heptenamide — ShangHaiChongDa Biotechnology Co Ltd](https://static.chemtradehub.com/suppliers/67ceca332b2de6e8e95a5684/67ceca332b2de6e8e95a5684-logo.webp){kind=logo}