Compound Q&A

How is (6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol (CAS: 722533-56-4) typically synthesized?

Answer

(6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol
This compound is synthesized via a multi-step process involving coupling reactions, aminations, and hydrolysis. Key steps include the synthesis of a benzyl ethylamine intermediate, followed by its coupling with a 4-methoxyaniline derivative. The reaction is catalyzed by palladium under mild conditions, with yields typically ranging from 60% to 75%.

About

English Name (6R)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol
Molecular Formula C30H38N2O2
Molecular Weight 458.65 g/mol
SMILES CCNCCc1ccc(cc1)CN(CC)c2cc(ccc2[C@@H]3CCc4cc(ccc4C3)O)OC
InChIKey SIFNOOUKXBRGGB-AREMUKBSSA-N
Last Updated: 2025-12-28 14:56

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