Compound Q&A
How is 4-[(1R)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (CAS: 190000-46-5) typically synthesized?
Answer
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4-[(1R)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride is typically synthesized via a multi-step process involving the reaction of 2,3-dimethylaniline with ethyl acetoacetate. The reaction is catalyzed by a Lewis acid such as aluminum chloride, and the product is isolated by crystallization from an aqueous solution. The yield is around 75-80%, and the product is usually obtained as a hydrochloride salt.
About
CAS No
190000-46-5
English Name
4-[(1R)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)
Molecular Formula
C13H17ClN2
Molecular Weight
236.75 g/mol
SMILES
Cl.C[C@@H](c1cnc[nH]1)c2cccc(C)c2C
InChIKey
VPNGEIHDPSLNMU-RFVHGSKJSA-N
Last Updated: 2025-12-28 10:59
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