How is (17beta)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one (CAS: 122370-91-6) typically synthesized?

(17beta)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one can be synthesized through the reduction of 6-methyleneandrosta-1,4-dien-3-one followed by an epoxidation and hydrolysis reaction. Commonly, the reduction is carried out using lithium aluminum hydride (LAH) or sodium borohydride, and the subsequent steps involve the use of peracids or sodium hydroxide to achieve the desired product. The overall yield is around 70-80%, and specific catalysts and conditions are necessary to achieve high selectivity and purity.