Compound Q&A
How is (2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile (CAS: 1036959-27-9) typically synthesized?
Answer
![(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile](https://static.chemtradehub.com/structs/103/1036959-27-9-f5ee.webp "(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile")
(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile can be synthesized via a multi-step reaction involving the condensation of 3-hydroxyadamantan-1-ylglycine with 2-pyrrolidinone. The reaction is catalyzed by a suitable base, and the product is isolated by recrystallization from an organic solvent. The yield is typically around 70-80%, with high selectivity towards the (2R) configuration.
About
CAS No
1036959-27-9
English Name
(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile
Molecular Formula
C17H25N3O2
Molecular Weight
292.42 g/mol
SMILES
OC1(CC2CC3C1)CC(C2)(C3)NCC(=O)N4CCC[C@@H]4C#N
InChIKey
SYOKIDBDQMKNDQ-JULPFRMLSA-N
Last Updated: 2025-12-28 10:59
![(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile — ShenZhenZhenJiangShengWuJiShu Co Ltd](https://static.chemtradehub.com/suppliers/67cec9142b2de6e8e95a51e7/67cec9142b2de6e8e95a51e7-logo.webp){kind=logo}
![(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile — Hubei Hongxin Chemical Reagents Co., Ltd.](https://static.chemtradehub.com/suppliers/67cde4c357537e5c8069aee2/67cde4c357537e5c8069aee2-logo.webp){kind=logo}
![(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}
![(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile — HuangDanYongXin Biotechnology Co Ltd](https://static.chemtradehub.com/suppliers/67cecadb2b2de6e8e95a5869/67cecadb2b2de6e8e95a5869-logo.webp){kind=logo}