(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile(CAS: 1036959-27-9)

(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile is a solid crystalline compound with a molecular weight of approximately 317.36 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetonitrile. The compound is stable under normal conditions but reacts with strong bases to form pyrrolidine carboxylates. It is used in research and pharmaceutical applications due to its unique chemical structure.

(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile can be synthesized via a multi-step reaction involving the condensation of 3-hydroxyadamantan-1-ylglycine with 2-pyrrolidinone. The reaction is catalyzed by a suitable base, and the product is isolated by recrystallization from an organic solvent. The yield is typically around 70-80%, with high selectivity towards the (2R) configuration.

(2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile is primarily used in the pharmaceutical industry for the development of novel drugs. It is also utilized in the polymer industry for the synthesis of special polymers and in the research fields of sensors and semiconductors for its unique chemical properties.

When handling (2R)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure. In case of a spill, the area should be ventilated and cleaned with an appropriate solvent. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.