Compound Q&A
How is (R,S)Palonosetron hydrochloride (CAS: 135755-51-0) typically synthesized?
Answer
(R,S)Palonosetron hydrochloride is synthesized through a multi-step process involving the synthesis of the 5-phenylpiperidine scaffold, followed by the attachment of the 5-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl) substituent. The key steps include N-alkylation, ring closure, and final hydrochloride salt formation. The yield is typically around 75%, with good selectivity towards the desired enantiomer.
About
CAS No
135755-51-0
English Name
(R,S)Palonosetron hcl
Molecular Formula
C19H25ClN2O
Molecular Weight
332.87 g/mol
SMILES
C1CC2CN(C(=O)C3=C2C(=CC=C3)C1)C4CN5CCC4CC5.Cl
InChIKey
OLDRWYVIKMSFFB-UHFFFAOYSA-N
Last Updated: 2025-12-25 18:29
