(R,S)Palonosetron hcl(CAS: 135755-51-0)

(R,S)Palonosetron hydrochloride is a crystalline compound with a molecular weight of approximately 436.52 g/mol. It is sparingly soluble in water and ethanol, and practically insoluble in acetone. The compound is stable under normal conditions but may react with bases to form the free base. It has a pKa of 1.40.

(R,S)Palonosetron hydrochloride is synthesized through a multi-step process involving the synthesis of the 5-phenylpiperidine scaffold, followed by the attachment of the 5-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl) substituent. The key steps include N-alkylation, ring closure, and final hydrochloride salt formation. The yield is typically around 75%, with good selectivity towards the desired enantiomer.

(R,S)Palonosetron hydrochloride is primarily used in the pharmaceutical industry for the prevention of chemotherapy-induced nausea and vomiting. It is also of interest in research for its analgesic and antiemetic properties. While not extensively used in other industries, it may have applications in polymer science and drug delivery systems.

When handling (R,S)Palonosetron hydrochloride, it is recommended to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation. Spills should be cleaned up using an appropriate absorbent material, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for the most up-to-date information on handling and storage guidelines.