Compound Q&A
How is N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide (CAS: 1421373-99-0) typically synthesized?
Answer
![N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide](https://static.chemtradehub.com/structs/142/1421373-99-0-b8f4.webp "N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide")
N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide is typically synthesized through multi-step reactions involving amidation, acylation, and coupling reactions. The synthesis often employs catalysts such as pyridine or triethylamine and typically yields 70-80% on a gram scale basis.
About
CAS No
1421373-99-0
English Name
N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide
Molecular Formula
C27H31N7O2
Molecular Weight
485.59 g/mol
SMILES
CNCCN(C)c1cc(c(cc1NC(=O)C=C)Nc2nccc(n2)c3cn(c4c3cccc4)C)OC
InChIKey
ZROCWKZRGJYPTG-UHFFFAOYSA-N
Last Updated: 2025-12-25 04:58
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