N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide(CAS: 1421373-99-0)

N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide is a crystalline solid with a molecular weight of approximately 617.74 g/mol. It has low water solubility and moderate solubility in organic solvents like DMF and DMSO. This compound exhibits moderate reactivity, particularly under basic conditions, and is stable under acidic conditions.

N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide is typically synthesized through multi-step reactions involving amidation, acylation, and coupling reactions. The synthesis often employs catalysts such as pyridine or triethylamine and typically yields 70-80% on a gram scale basis.

N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide finds application in the pharmaceutical industry for the development of novel drugs. It is also used in the research of sensors and semiconductors due to its unique chemical structure and potential biological activities.

When handling N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide, it is essential to use personal protective equipment, including gloves, safety glasses, and a lab coat. Work in a well-ventilated area or fume hood due to its potential reactivity. Spills should be handled with appropriate absorbents and disposed of according to the Material Safety Data Sheet (MSDS) guidelines.