How is Ethyl 2,2-difluoro-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoate (CAS: 847986-13-4) typically synthesized?

Ethyl 2,2-difluoro-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoate can be synthesized via a multi-step reaction sequence involving protective group chemistry and acylation. It typically involves the conversion of a primary alcohol to its corresponding acyl chloride, followed by the formation of the amino ester. The key catalysts used include acid anhydrides or acyl chlorides, and the process often requires mild to moderate heating. The overall yield can range from 50% to 70%.