Compound Q&A
How is [3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile (CAS: 396131-82-1) typically synthesized?
Answer
![[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile](https://static.chemtradehub.com/structs/396/396131-82-1-a321.webp "[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile")
[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile is typically synthesized through a multistep process. The key step involves the reaction of phenylacetonitrile with 1,3,2-dioxaborine in the presence of a palladium catalyst and a base. The yield is generally around 70-80%, with good selectivity. This synthesis is commonly used in organoboron chemistry.
About
CAS No
396131-82-1
English Name
[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile
Molecular Formula
C14H18BNO2
Molecular Weight
243.11 g/mol
SMILES
B1(OC(C(O1)(C)C)(C)C)C2=CC(=CC=C2)CC#N
InChIKey
LIWPKYSGWSFPEE-UHFFFAOYSA-N
Last Updated: 2025-11-27 19:31
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