Compound Q&A
How is 1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(2-pyridinylmethyl)methanesulfonamide (CAS: 1001917-37-8) typically synthesized?
Answer
![1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(2-pyridinylmethyl)methanesulfonamide](https://static.chemtradehub.com/structs/100/1001917-37-8-4494.webp "1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(2-pyridinylmethyl)methanesulfonamide")
This compound is synthesized via a multi-step process involving the condensation of pyridinylmethylamine with the corresponding sulfonyl chloride derivative, followed by coupling with the pyrazolo[1,5-a]pyridine ring. The reaction is typically performed in the presence of a base such as triethylamine, and the overall yield is around 70-80%.
About
CAS No
1001917-37-8
English Name
1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(2-pyridinylmethyl)methanesulfonamide
Molecular Formula
C25H21N5O3S
Molecular Weight
471.54 g/mol
SMILES
Cn1ncc(c1)c1cnc2c(c1)c(=O)c1cc(ccc1cc2)CS(=O)(=O)NCc1ccccn1
InChIKey
VMJFTOSOFDEKTM-UHFFFAOYSA-N
Last Updated: 2025-11-08 00:00
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