Compound Q&A
How is 2R,4S-Sacubitril (CAS: 761373-05-1) typically synthesized?
Answer
2R,4S-Sacubitril is synthesized through a multi-step process involving the coupling of 2-aminobutane-1-sulfonamide and 4-hydroxy-1-(2-pyridinyl)-1-butene. The reaction typically requires a palladium catalyst and proceeds in the presence of a base such as triethylamine. The overall yield of the synthesis is around 75-80%, with good selectivity for the desired stereoisomer.
About
CAS No
761373-05-1
English Name
2R,4S-Sacubitril
Molecular Formula
C24H29NO5
Molecular Weight
411.49800000000016 g/mol
SMILES
CCOC(=O)[C@@H](C)C[C@H](Cc1ccc(cc1)c2ccccc2)NC(=O)CCC(=O)O
InChIKey
PYNXFZCZUAOOQC-LAUBAEHRSA-N
Last Updated: 2025-11-08 00:00
