2R,4S-Sacubitril(CAS: 761373-05-1)

2R,4S-Sacubitril is a white to off-white crystalline powder with a molecular weight of approximately 273.34 g/mol. It has a solubility of about 0.109 mg/mL in water. The compound is moderately reactive, particularly with strong acids and bases. It has good stability under normal storage conditions, but should be protected from moisture and heat.

2R,4S-Sacubitril is synthesized through a multi-step process involving the coupling of 2-aminobutane-1-sulfonamide and 4-hydroxy-1-(2-pyridinyl)-1-butene. The reaction typically requires a palladium catalyst and proceeds in the presence of a base such as triethylamine. The overall yield of the synthesis is around 75-80%, with good selectivity for the desired stereoisomer.

2R,4S-Sacubitril is primarily used in the pharmaceutical industry, specifically in the formulation of sacubitril/valsartan for the treatment of heart failure. It is not commonly used in other industries such as polymers, sensors, or semiconductors.

When handling 2R,4S-Sacubitril, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place, away from incompatible materials. Spills should be handled with care, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.