Compound Q&A

How is 2-Methoxy-5-(2-methyl-2-propanyl)aniline (CAS: 3535-88-4) typically synthesized?

Answer

2-Methoxy-5-(2-methyl-2-propanyl)aniline
2-Methoxy-5-(2-methyl-2-propanyl)aniline is typically synthesized via a Friedel-Crafts alkylation of 2-methoxyaniline with 2-methyl-2-propanol in the presence of aluminum chloride as a catalyst. The yield is usually around 80%, and the product is purified by recrystallization. This method ensures good selectivity and efficiency, making it a common route for its industrial production.

About

CAS No 3535-88-4
English Name 2-Methoxy-5-(2-methyl-2-propanyl)aniline
Molecular Formula C11H17NO
Molecular Weight 179.26 g/mol
SMILES CC(C)(C)C1=CC(=C(C=C1)OC)N
InChIKey DLTLFDQLMFMTRQ-UHFFFAOYSA-N
Last Updated: 2025-11-07 15:33

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