Compound Q&A
How is Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate (CAS: 71145-03-4) typically synthesized?
Answer
![Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate](https://static.chemtradehub.com/structs/711/71145-03-4-1673.webp "Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate")
Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate is synthesized via a multi-step process involving the reaction of 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridine with acetic anhydride. The reaction is catalyzed by an acid, typically sulfuric acid, under reflux conditions. The yield is around 85%, and the product is purified by recrystallization.
About
CAS No
71145-03-4
English Name
Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3-pyridinecarboxylate
Molecular Formula
C16H15F3N2O4
Molecular Weight
356.3 g/mol
SMILES
CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
InChIKey
ZFLWDHHVRRZMEI-UHFFFAOYSA-N
Last Updated: 2025-11-07 15:33
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