How is Methyl (2E)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate (CAS: 105392-26-5) typically synthesized?

Methyl (2E)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate is synthesized via a multi-step process involving the formation of a key intermediate. The synthesis typically involves the coupling of a cyclopropylamine with a 2,4-dichloro-5-fluorobenzoyl chloride, followed by acylation of the resulting intermediate with methyl acrylate. The reaction conditions include the use of a suitable catalyst and the appropriate temperature to achieve high selectivity and yield.