Methyl (2E)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate(CAS: 105392-26-5)

Methyl (2E)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate is a crystalline solid with a molecular weight of approximately 358.04 g/mol. It has a low solubility in water but is soluble in common organic solvents like acetonitrile and dimethylformamide. The compound is relatively stable but can undergo hydrolysis under basic conditions. It is not highly reactive but should be handled with care due to its chlorinated and fluorinated substituents.

Methyl (2E)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate is synthesized via a multi-step process involving the formation of a key intermediate. The synthesis typically involves the coupling of a cyclopropylamine with a 2,4-dichloro-5-fluorobenzoyl chloride, followed by acylation of the resulting intermediate with methyl acrylate. The reaction conditions include the use of a suitable catalyst and the appropriate temperature to achieve high selectivity and yield.

Methyl (2E)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate is primarily used in the pharmaceutical industry for the synthesis of pharmaceutical intermediates. It is also utilized in the polymer industry as a monomer for the production of specialty polymers. Additionally, it has applications in the development of sensors and semiconductors due to its functional groups and chemical stability.

When handling Methyl (2E)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluorobenzoyl)acrylate, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated environment or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.