Compound Q&A
How is 1-(3-Chlorophenyl)piperazine Dihydrochloride (CAS: 51639-49-7) typically synthesized?
Answer
1-(3-Chlorophenyl)piperazine dihydrochloride is synthesized by the condensation of 3-chlorophenylamine with piperazine, followed by the addition of hydrochloric acid to form the dihydrochloride salt. Commonly, this reaction is carried out in the presence of a suitable solvent like ethanol at room temperature. The yield is around 70-80%, and the product is purified by recrystallization from water or ethanol.
About
CAS No
51639-49-7
English Name
1-(3-Chlorophenyl)piperazine Dihydrochloride
Molecular Formula
C10H15Cl3N2
Molecular Weight
269.603 g/mol
SMILES
C1CN(CCN1)C2=CC(=CC=C2)Cl.Cl.Cl
InChIKey
OSZCTRWSGNWWBL-UHFFFAOYSA-N
Last Updated: 2025-11-05 07:29