Compound Q&A
How is Boc-2-(trifluoromethyl)-L-phenylalanine (CAS: 167993-21-7) typically synthesized?
Answer
Boc-2-(trifluoromethyl)-L-phenylalanine (CAS: 167993-21-7) is synthesized via a multi-step process involving the protection of the carboxylic acid group of L-phenylalanine with叔丁氧羰基 (Boc) followed by attachment of a trifluoromethyl group. This is achieved through the coupling of Boc-phenylalanine with trifluoromethyl chloroformate in the presence of a base, such as diisopropylamine, yielding the desired product with good yield and selectivity.
About
CAS No
167993-21-7
English Name
Boc-2-(trifluoromethyl)-L-phenylalanine
Molecular Formula
C15H18F3NO4
Molecular Weight
333.3 g/mol
SMILES
CC(C)(C)OC(=O)NC(CC1=CC=CC=C1C(F)(F)F)C(=O)O
InChIKey
XKMOOODKNPYTEE-NSHDSACASA-N
Last Updated: 2025-11-05 07:29
