Compound Q&A

How is N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide (CAS: 932986-18-0) typically synthesized?

Answer

N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide
N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide is typically synthesized through a multi-step process involving the coupling of 4-chloroaniline with thiazole, followed by butylation. This process often uses coupling agents such as EDC and NHS, and the reaction is carried out in the presence of a base like triethylamine. The overall yield is moderate, around 50-70%, and the reaction is conducted under mild conditions to ensure high selectivity.

About

English Name N-(2-(2-(4-Chlorophenyl)thiazol-4-YL)ethyl)butyramide
Molecular Formula C15H17ClN2OS
Molecular Weight 308.83400000000006 g/mol
SMILES CCCC(=O)NCCC1=CSC(=N1)C2=CC=C(C=C2)Cl
InChIKey VYBFWKKCWTXCQX-UHFFFAOYSA-N
Last Updated: 2025-11-04 22:30

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