How is (S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate (CAS: 1000414-38-9) typically synthesized?

(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate can be synthesized via a multi-step process starting from benzofuran derivatives. Common methods involve protection of the hydroxyl group, followed by acylation, and subsequent deprotection. The reaction typically requires a chiral auxiliary for enantioselective synthesis, leading to a yield of up to 85%. The process usually involves the use of transition metal catalysts and organic solvents.