Compound Q&A
How is 8-(Trifluoromethyl)quinoline (CAS: 317-57-7) typically synthesized?
Answer
8-(Trifluoromethyl)quinoline (CAS: 317-57-7) is typically synthesized through a condensation reaction of 2-chloroquinoline with trifluoromethyl ketone in the presence of a base like potassium carbonate. The reaction proceeds via an intramolecular Friedel-Crafts alkylation followed by a rearrangement step. Yields are generally high, and the process can be optimized using microwave heating to enhance reactivity and selectivity.
About
CAS No
317-57-7
English Name
8-(Trifluoromethyl)quinoline
Molecular Formula
C10H6F3N
Molecular Weight
197.16 g/mol
SMILES
C1=CC2=C(C(=C1)C(F)(F)F)N=CC=C2
InChIKey
AJXUSUNIYLSPER-UHFFFAOYSA-N
Last Updated: 2025-11-04 13:04
