How is (Z)-N~5~-[Amino(dimethylamino)methylene]-L-ornithine dihydrochloride (CAS: 220805-22-1) typically synthesized?

The (Z)-N~5~-[Amino(dimethylamino)methylene]-L-ornithine dihydrochloride (CAS: 220805-22-1) is synthesized through a multi-step process involving the reaction of L-ornithine with dimethylamine in the presence of a suitable catalyst. The yield typically ranges from 70% to 80%, with high selectivity for the desired dihydrochloride product. Commonly used solvents include ethanol and water, and the reaction is conducted under mild conditions to ensure product purity.