Compound Q&A
How is TIPA (CAS: 144970-30-9) typically synthesized?
Answer
TIPA (1,1,1,3,3,3-Hexafluoropropan-2-ol) is usually synthesized by the fluorination of propan-2-ol. This process involves the reaction of propan-2-ol with fluorine gas in the presence of a Lewis acid catalyst, such as iron (III) chloride or aluminum chloride. The reaction is conducted under anhydrous conditions to prevent side reactions. The yield of TIPA can be as high as 85-90%, with good selectivity towards the desired product.
About
CAS No
144970-30-9
English Name
TIPA
Molecular Formula
C34H28I4
Molecular Weight
944.2140000000002 g/mol
SMILES
Ic1ccc(cc1)C12CC3(CC(C2)(CC(C1)(C3)c1ccc(cc1)I)c1ccc(cc1)I)c1ccc(cc1)I
InChIKey
HTGPRXPCTBXRBH-UHFFFAOYSA-N
Last Updated: 2025-11-01 18:55
