Compound Q&A
How is N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (CAS: 149765-15-1) typically synthesized?
Answer
![N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide](https://static.chemtradehub.com/structs/149/149765-15-1-385b.webp "N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide")
N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (CAS: 149765-15-1) is synthesized through a multi-step process, involving the synthesis of the 4-chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl moiety, followed by a condensation reaction with 2,2-dimethylpropanoyl chloride. The reaction typically uses a palladium catalyst and a base such as potassium carbonate. The yield of this reaction is around 75-85%.
About
CAS No
149765-15-1
English Name
N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide
Molecular Formula
C11H13ClN4O
Molecular Weight
252.71 g/mol
SMILES
CC(C)(C)C(=O)NC1=NC2=C(C=CN2)C(=N1)Cl
InChIKey
HNBVXLCVUIJCSK-UHFFFAOYSA-N
Last Updated: 2025-11-01 12:59
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