N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide(CAS: 149765-15-1)

N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (CAS: 149765-15-1) is a crystalline compound with a molecular weight of approximately 317.65 g/mol. It has a low solubility in water but is soluble in organic solvents like DMSO and DMF. The compound is moderately reactive, showing affinity for nucleophilic substitution reactions. It is used in pharmaceutical applications due to its biological activity.

N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (CAS: 149765-15-1) is synthesized through a multi-step process, involving the synthesis of the 4-chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl moiety, followed by a condensation reaction with 2,2-dimethylpropanoyl chloride. The reaction typically uses a palladium catalyst and a base such as potassium carbonate. The yield of this reaction is around 75-85%.

N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (CAS: 149765-15-1) is primarily used in the pharmaceutical industry due to its potential as an active pharmaceutical ingredient. It is also of interest in academia and research for its biological activity and can be used in the development of new drugs. This compound has potential applications in polymer science and electronic materials as well.

When handling N-(4-Chloro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (CAS: 149765-15-1), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. Spills should be managed using appropriate containment and disposal methods. Always consult the Material Safety Data Sheet (MSDS) for detailed information on safety and handling procedures.