Compound Q&A
How is N-[3-(Trifluoromethyl)benzoyl]glycine (CAS: 17794-48-8) typically synthesized?
Answer
![N-[3-(Trifluoromethyl)benzoyl]glycine](https://static.chemtradehub.com/structs/177/17794-48-8-485b.webp "N-[3-(Trifluoromethyl)benzoyl]glycine")
N-[3-(Trifluoromethyl)benzoyl]glycine (CAS: 17794-48-8) is typically synthesized via a multi-step process involving the condensation of glycine with 3-(trifluoromethyl)benzoic acid in the presence of a coupling reagent such as HATU and a base like DIPEA. The yield is around 85%, and the product is purified by column chromatography or recrystallization.
About
CAS No
17794-48-8
English Name
N-[3-(Trifluoromethyl)benzoyl]glycine
Molecular Formula
C10H8F3NO3
Molecular Weight
247.17 g/mol
SMILES
C1=CC(=CC(=C1)C(F)(F)F)C(=O)NCC(=O)O
InChIKey
ZDGGJQMSELMHLK-UHFFFAOYSA-N
Last Updated: 2025-11-01 12:59
![N-[3-(Trifluoromethyl)benzoyl]glycine — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}
![N-[3-(Trifluoromethyl)benzoyl]glycine — Huifei Mokai Medicinal Technology Co., Ltd.](https://static.chemtradehub.com/suppliers/67cdef8657537e5c8069afb0/67cdef8657537e5c8069afb0-logo.webp){kind=logo}