Compound Q&A
How is 1-Chloro-3,5-bis(trifluoromethyl)benzene (CAS: 328-72-3) typically synthesized?
Answer
1-Chloro-3,5-bis(trifluoromethyl)benzene (CAS: 328-72-3) can be synthesized via the Friedel-Crafts alkylation of 1-chlorobenzene (or benzene) with trifluoromethyl chloromethane in the presence of aluminum chloride as a catalyst. The reaction is typically carried out under anhydrous conditions to achieve high yield and selectivity. The product is usually purified by recrystallization or column chromatography.
About
CAS No
328-72-3
English Name
1-Chloro-3,5-bis(trifluoromethyl)benzene
Molecular Formula
C8H3ClF6
Molecular Weight
248.55 g/mol
SMILES
C1=C(C=C(C=C1C(F)(F)F)Cl)C(F)(F)F
InChIKey
OXMBWPJFVUPOFO-UHFFFAOYSA-N
Last Updated: 2025-10-31 20:53
