Compound Q&A

How is Tfa-VAL-TYR-VAL-OH (CAS: 64577-63-5) typically synthesized?

Answer

Tfa-VAL-TYR-VAL-OH
Tfa-VAL-TYR-VAL-OH (CAS: 64577-63-5) is synthesized through peptide coupling reactions. Commonly, the synthesis involves the sequential coupling of individual amino acid equivalents (TFA-protected) using HATU or EDC/NHS as coupling reagents. The coupling is typically performed in anhydrous organic solvents like DCM or DMF. The final product is obtained with high selectivity and yield, usually around 80-90%.

About

CAS No 64577-63-5
English Name Tfa-VAL-TYR-VAL-OH
Molecular Formula C21H28F3N3O6
Molecular Weight 475.5 g/mol
SMILES CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)C)C(=O)O)NC(=O)C(F)(F)F
InChIKey SAVSLMGBKQKUAV-JYJNAYRXSA-N
Last Updated: 2025-10-29 13:16

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