Compound Q&A

How is (R)-Dtbm-segphos (CAS: 566940-03-2) typically synthesized?

Answer

(R)-Dtbm-segphos
(R)-Dtbm-segphos is typically synthesized through asymmetric synthesis methods, utilizing chiral auxiliaries and transition metal catalysts. The process involves protecting group manipulation and chiral pool chemistry, yielding a product with excellent enantioselectivity. The overall yield ranges from 70% to 90%, depending on the specific reaction conditions.

About

English Name (R)-Dtbm-segphos
Molecular Formula C74H100O8P2
Molecular Weight 1179.5539999999985 g/mol
SMILES CC(C)(C)C1=CC(=CC(=C1OC)C(C)(C)C)P(C2=C(C3=C(C=C2)OCO3)C4=C(C=CC5=C4OCO5)P(C6=CC(=C(C(=C6)C(C)(C)C)OC)C(C)(C)C)C7=CC(=C(C(=C7)C(C)(C)C)OC)C(C)(C)C)C8=CC(=C(C(=C8)C(C)(C)C)OC)C(C)(C)C
InChIKey ZNORAFJUESSLTM-UHFFFAOYSA-N
Last Updated: 2025-10-29 13:16

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