How is (2S)-3-(2,4-difluorophenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid (CAS: 1032337-49-7) typically synthesized?

The compound is usually synthesized via multistep reactions involving protection of the amino group, coupling of the fluorenylmethoxy carbonyl group, and deprotection. Commonly used reagents include fluorenylmethanol, di-tert-butyl dicarbonate, and TFA (trifluoroacetic acid). The synthesis requires careful control of reaction conditions to achieve high yields and selectivity.