Compound Q&A
How is Neuropeptide FF H-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (CAS: 99566-27-5) typically synthesized?
Answer
Neuropeptide FF is synthesized using solid-phase peptide synthesis (SPPS) techniques. The process involves the stepwise addition of protected amino acids to an Fmoc-protected resin. Commonly, the Fmoc deprotection is followed by coupling with the next amino acid, typically using HATU or BOP as the coupling reagent. The peptide is then cleaved from the resin using strong acid, such as trifluoroacetic acid (TFA), to yield the final product.
About
CAS No
99566-27-5
English Name
Neuropeptide FF H-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2
Molecular Formula
C54H76N14O10
Molecular Weight
1081.3 g/mol
SMILES
CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCC(=O)N)C(=O)N2CCCC2C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=CC=C4)N
InChIKey
HWYCFZUSOBOBIN-AQJXLSMYSA-N
Last Updated: 2025-10-29 13:16
